Analysis of the small RNA transcriptional response in multidrug-resistant Staphylococcus aureus after antimicrobial exposure.

@article{Howden2013AnalysisOT,
  title={Analysis of the small RNA transcriptional response in multidrug-resistant Staphylococcus aureus after antimicrobial exposure.},
  author={Benjamin P Howden and Marie Beaume and Paul F Harrison and David Pescador Hern{\'a}ndez and Jacques Schrenzel and Torsten Seemann and Patrice François and Timothy P Stinear},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 8},
  pages={3864-74}
}
The critical role of noncoding small RNAs (sRNAs) in the bacterial response to changing conditions is increasingly recognized. However, a specific role for sRNAs during antibiotic exposure has not been investigated in Staphylococcus aureus. Here, we used Illumina RNA-Seq to examine the sRNA response of multiresistant sequence type 239 (ST239) S. aureus after exposure to four antibiotics (vancomycin, linezolid, ceftobiprole, and tigecycline) representing the major classes of antimicrobials used… CONTINUE READING
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