Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages.

@article{Kengatharan1996AnalysisOT,
  title={Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages.},
  author={Muralitharan Kengatharan and Sjef J. de Kimpe and Christoph Thiemermann},
  journal={British journal of pharmacology},
  year={1996},
  volume={117 6},
  pages={1163-70}
}
1. This study investigates the signal transduction mechanisms leading to the enhanced formation of nitric oxide (NO) due to the induction of NO synthase (iNOS) in murine J774.2 macrophages in culture activated with lipoteichoic acid (LTA), a cell wall component of the gram-positive bacterium Staphylococcus aureus. 2. LTA (10 microgram ml-1) caused within 24 h an enhanced accumulation of nitrite (an indicator of NO biosynthesis) in the supernatant of J774.2 macrophages which was prevented by the… CONTINUE READING