Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.

@article{Ito2005AnalysisOT,
  title={Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.},
  author={Toshiro Ito and Takuya Ueno and Michael R. Clarkson and Xueli Yuan and Mollie M. Jurewicz and H. Yagita and Miyuki Azuma and Arlene H Sharpe and Hugh Auchincloss and Mohamed H. Sayegh and Nader Najafian},
  journal={Journal of immunology},
  year={2005},
  volume={174 11},
  pages={6648-56}
}
Negative costimulatory signals mediated via cell surface molecules such as CTLA-4 and programmed death 1 (PD-1) play a critical role in down-modulating immune responses and maintaining peripheral tolerance. However, their role in alloimmune responses remains unclear. This study examined the role of these inhibitory pathways in regulating CD28-dependent and CD28-independent CD4 and CD8 alloreactive T cells in vivo. CTLA-4 blockade accelerated graft rejection in C57BL/6 wild-type recipients and… CONTINUE READING
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