Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity.

@article{Fry1983AnalysisOT,
  title={Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity.},
  author={David W. Fry and Lisa A Anderson and Martin Borst and I. David Goldman},
  journal={Cancer research},
  year={1983},
  volume={43 3},
  pages={1087-92}
}
The synthesis and retention of methotrexate polyglutamate derivatives were evaluated in the Ehrlich ascites tumor cell and the intestinal mucosa in vivo. When tumor-bearing mice re ceived injections of methotrexate (12 mg/kg), polyglutamate derivatives accumulated within the tumor cells as long as intracellular methotrexate was above the dihydrofolate reductase-binding capacity, the metabolites themselves reaching concentrations in excess of this level. Methotrexate attained maximum… CONTINUE READING

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