Analysis of the role of intraprotein electron transfer in photoreactivation by DNA photolyase in vivo.

@article{Kavakli2004AnalysisOT,
  title={Analysis of the role of intraprotein electron transfer in photoreactivation by DNA photolyase in vivo.},
  author={I. Halil Kavakli and Aziz Sancar},
  journal={Biochemistry},
  year={2004},
  volume={43 48},
  pages={15103-10}
}
Escherichia coli DNA photolyase contains FADH(-) as the catalytic cofactor. The cofactor becomes oxidized to the FADH(*) blue neutral radical during purification. The E-FADH(*) form of the enzyme is catalytically inert but can be converted to the active E-FADH(-) form by a photoreduction reaction that involves intraprotein electron transfer from Trp306. It is thought that the E-FADH(*) form is also transiently generated during pyrimidine dimer repair by photoinduced electron transfer, and it… CONTINUE READING

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