Analysis of the role of glycosylation of the human fibronectin receptor.

  title={Analysis of the role of glycosylation of the human fibronectin receptor.},
  author={Steven K. Akiyama and Susan S. Yamada and Kenneth M Yamada},
  journal={The Journal of biological chemistry},
  volume={264 30},
1-Deoxymannojirimycin (MNJ), an inhibitor of Golgi alpha-mannosidase IA and IB, was used to assess the possible roles of asparagine-linked oligosaccharides in the structure and function of the integrin fibronectin receptor from cultured human fibroblasts. These cells normally attach well to fibronectin substrates and have only mature forms of the fibronectin receptor on their surfaces. MNJ inhibits the intracellular trimming of high mannose oligosaccharides, and cells treated with 0.2 mg/ml MNJ… CONTINUE READING


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