Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins.

@article{Mouna2016AnalysisOT,
  title={Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins.},
  author={Lina Mouna and Eva Hernandez and Dorine Bonte and Rebekka Brost and Larbi Amazit and Laura Ruth Delgui and Wolfram Brune and Adam P. Geballe and Isabelle Beau and Audrey Esclatine},
  journal={Autophagy},
  year={2016},
  volume={12 2},
  pages={327-42}
}
Autophagy is activated early after human cytomegalovirus (HCMV) infection but, later on, the virus blocks autophagy. Here we characterized 2 HCMV proteins, TRS1 and IRS1, which inhibit autophagy during infection. Expression of either TRS1 or IRS1 was able to block autophagy in different cell lines, independently of the EIF2S1 kinase, EIF2AK2/PKR. Instead, TRS1 and IRS1 interacted with the autophagy protein BECN1/Beclin 1. We mapped the BECN1-binding domain (BBD) of IRS1 and TRS1 and found it to… CONTINUE READING
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