Analysis of the role of 5-HT in the enteric nervous system using anti-idiotopic antibodies to 5-HT receptors.

@article{Wade1994AnalysisOT,
  title={Analysis of the role of 5-HT in the enteric nervous system using anti-idiotopic antibodies to 5-HT receptors.},
  author={Paul R. Wade and Hadassah Tamir and Annette L Kirchgessner and Michael David Gershon},
  journal={The American journal of physiology},
  year={1994},
  volume={266 3 Pt 1},
  pages={G403-16}
}
The effects of anti-idiotypic antibodies (alpha-id) that recognize serotonin [5-hydroxytryptamine (5-HT)] receptors on myenteric neurons of the guinea pig small intestine were characterized electrophysiologically, and alpha-id binding sites were located immunocytochemically. Initial applications of the alpha-id mimicked each of three actions of 5-HT: a rapid depolarization, associated with a fall in input resistance (Rin), which was inhibited by the 5-HT3 antagonists tropisetron (> or = 1… CONTINUE READING

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