Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia.

@article{Aitken1989AnalysisOT,
  title={Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia.},
  author={R J Aitken and J. Shannon Clarkson and Timothy B. Hargreave and D. Stewart Irvine and Frederick C W Wu},
  journal={Journal of andrology},
  year={1989},
  volume={10 3},
  pages={
          214-20
        }
}
The ability of human spermatozoa to exhibit sperm-oocyte fusion in response to the ionophore, A23187, was examined in relation to the capacity of these cells to generate reactive oxygen species. In 70 fertile control donors, there was an overwhelming pattern of high levels of sperm-oocyte fusion associated with low levels of reactive oxygen species production. By contrast, 88% of the 74 oligozoospermic patients exhibited less than 25% oocyte penetration in response to A23187 and 58% exhibited… CONTINUE READING

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