Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme.

@article{Rice1990AnalysisOT,
  title={Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme.},
  author={Douglas A. Rice and Marian Sue Kirkman and Lisa Aitken and A R Mouw and Bernard P. Schimmer and Keith L. Parker},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 20},
  pages={11713-20}
}
The cholesterol side-chain cleavage enzyme (SCC) catalyzes the initial and rate-limiting step in the synthesis of steroid hormones. The mouse gene encoding SCC was cloned and the nucleotide sequence of its 5'-flanking region determined. This sequence includes an AP-1 motif at -319 and two motifs, AGGTCA at -70 and AGCCTTG at -40, that match elements proposed to be important in the expression of steroid 21-hydroxylase. When transfected into mouse Y1 adrenocortical tumor cells, 1.5 kilobase pairs… CONTINUE READING

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Germs & deu

  • J. Biol. Chem
  • 1989
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