Analysis of the principles underlying chemo-immunotherapy of mouse tumours


A CBA mouse fibrosarcoma (M4) growing as a solid tumour was treated with a single high dose (200 mg/kg) of cyclophosphamide (CY) followed by C. parvum (CP) immunotherapy. The optimal time for the administration of both nonspecific (CP IV) and active specific (SC CP-irradiated tumour cell mixtures) immunotherapy after CY was 4 days, compared with 1, 8, or 12… (More)
DOI: 10.1007/BF00200139


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