Analysis of the pharmacokinetics and metabolism of aloe-emodin following intravenous and oral administrations in rats.

Abstract

Aloe-emodin, a natural polyphenolic anthraquinone, has shown various beneficial bioactivities in vitro. The aim of this study was to investigate the pharmacokinetics and metabolism of aloe-emodin. Aloe-emodin was intravenously and orally administered to rats. The concentrations of aloe-emodin and rhein, a metabolite of aloe-emodin, were determined by HPLC method prior to and after hydrolysis with β-glucuronidase and sulfatase/β-glucuronidase. The results showed that the systemic exposures of aloe-emodin and its metabolites were ranked as aloe-emodin glucuronides (G) > rhein sulfates (S) > aloe-emodin > rhein and rhein G when aloe-emodin was given intravenously. In contrast, when aloe-emodin was administered orally, the parent form of aloe-emodin was not absorbed per se, and the systemic exposures of its metabolites were ranked as aloe-emodin G > rhein G > rhein. In conclusion, the metabolites of aloe-emodin are more important than the parent form for the bioactivities in vivo. Copyright © 2016 John Wiley & Sons, Ltd.

DOI: 10.1002/bmc.3735

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Cite this paper

@article{Yu2016AnalysisOT, title={Analysis of the pharmacokinetics and metabolism of aloe-emodin following intravenous and oral administrations in rats.}, author={Chung-Ping Yu and Chi-Sheng Shia and Hui-Ju Lin and Yow-Wen Hsieh and Shiuan-Pey Lin and Yu-Chi Hou}, journal={Biomedical chromatography : BMC}, year={2016}, volume={30 10}, pages={1641-7} }