Analysis of the persistence of humoral and cellular immunity in children and adults immunized with varicella vaccine.

@article{Zerboni1998AnalysisOT,
  title={Analysis of the persistence of humoral and cellular immunity in children and adults immunized with varicella vaccine.},
  author={Leigh Zerboni and S Nader and Kenji Aoki and Ann M. Arvin},
  journal={The Journal of infectious diseases},
  year={1998},
  volume={177 6},
  pages={
          1701-4
        }
}
The persistence of humoral and cellular immunity to varicella-zoster virus (VZV) was evaluated in 60 children and 18 adults immunized with live attenuated VZV vaccine. At a mean of 5 years after vaccination, 93% of children and 94% of adults had IgG antibodies to VZV as determined by ELISA. VZV antibody concentrations were significantly higher at 5 years than at 1 year after immunization in children and adults. Cell-mediated immunity to VZV was detected in 87% of children and 94% of adults at 5… 
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Humoral and cell-mediated immune responses in children and adults after 1 and 2 doses of varicella vaccine.
  • B. Watson
  • Medicine, Biology
    The Journal of infectious diseases
  • 2008
TLDR
Investigations of vaccine-induced immunity suggest that 2 doses of VZV vaccine will better achieve the goals of the V ZV vaccination program, by reducing the V zoster virus burden of disease in childhood and preventing accumulation of young adults who are susceptible to or only partially protected from varicella.
Effectiveness of live varicella vaccine
TLDR
Concerns have been raised that universal immunisation in children may shift the susceptibility from children to adults, whose symptoms are usually moderate-to-severe, and other concerns have been expressed that, due to lack of exposure to varicella in children, the elderly may develop zoster infections more frequently than before.
Persistence of Varicella-Zoster Virus-Specific Plasma Cells in Adult Human Bone Marrow following Childhood Vaccination
TLDR
It is shown in 15 healthy young adults that VZV-specific B and CD4 T cell responses are detectable in bone marrow (BM) and blood up to 20 years after vaccination, indicating that childhood VZv vaccination can elicit long-lived immune memory responses in the bone marrow.
Persistence of Immunity to Varicella-Zoster Virus After Vaccination of Healthcare Workers
TLDR
The VZV vaccine effectively protected HCWs from varicella, particularly from serious disease, and improved assays are needed.
Analysis of the Persistence of Humoral and Cellular Immunity inChildren and Adults Immunized With Varicella Vaccine
TLDR
The persistence of humoral and cellular immunity to varicella-zoster virus (VZV) in children and adults immunized with live attenuated VZV vaccine is evaluated.
Safety and immunogenicity of single dose live attenuated varicella vaccine (VR 795 Oka strain) in healthy Indian children: A randomized controlled study
TLDR
The test live attenuated vaccine was found to be highly immunogenic, safe and comparable to Varilrix used in control arm, and the adverse events were not different in the control and test groups.
Vaccines for post-exposure prophylaxis against varicella (chickenpox) in children and adults.
TLDR
These small trials suggest varicella vaccine administered within three days to children following household contact with avaricella case reduces infection rates and severity of cases.
Experience with live attenuated varicella vaccine (Oka strain) in healthy Japanese subjects; 10-year survey at pediatric clinic.
Consensus: Varicella Vaccination of Healthy Children: A Challenge for Europe
TLDR
Routinevaricella vaccination for all healthy children between 12 and 18 months and to all susceptible children before their 13th birthday, in addition to catch-up vaccination in older children and adults who have no reliable history of varicella and who are at high risk of transmission and exposure are recommended.
Update on varicella vaccine.
TLDR
The varicella vaccine can be given in immunocompromized children, including children with leukemia and bone marrow transplantation recipients, when immune function recovers, and can also reduce morbidity due tovaricella zoster virus reactivation in high-risk populations.
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