Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities.

@article{Sreevatsan1997AnalysisOT,
  title={Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities.},
  author={Srinand Sreevatsan and Xi Pan and Ying Zhang and Vojo Deretic and James M. Musser},
  journal={Antimicrobial agents and chemotherapy},
  year={1997},
  volume={41 3},
  pages={
          600-6
        }
}
Automated DNA sequencing was used to analyze the oxyR-ahpC region in 229 Mycobacterium tuberculosis complex isolates recently recovered from diseased humans and animals. The entire 1,221-bp region was studied in 118 isolates, and 111 other isolates were sequenced for oxyR, ahpC, or the 105-bp oxyR-ahpC intergenic region. The sample included isoniazid (INH)-susceptible and -resistant organisms in which the katG gene and inhA locus had previously been sequenced in their entirety to identify… CONTINUE READING
Highly Cited
This paper has 62 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Significance ofahpC promoter mutations for the prediction of isoniazid resistance inMycobacterium tuberculosis

European Journal of Clinical Microbiology and Infectious Diseases • 2005
View 9 Excerpts
Highly Influenced

Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives.

Emerging infectious diseases • 1998
View 4 Excerpts
Highly Influenced

63 Citations

0510'97'02'08'14
Citations per Year
Semantic Scholar estimates that this publication has 63 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 3 Excerpts
Highly Influenced

Identification of a polymorphic nucleotide in oxyR specific for Mycobacterium bovis

S. Srinand, P. Escalante, +11 authors J. M. Musser
J. Clin. Microbiol • 1996
View 1 Excerpt

Antimicrobial agents and susceptibility tests: mycobacteria, p. 1385–1404

C. B. Inderlied, M. Salfinger
Manual of clinical microbiology, • 1995