Analysis of the nicastrin promoter rs10752637 polymorphism and its association with Alzheimer's disease.

@article{Zhong2009AnalysisOT,
  title={Analysis of the nicastrin promoter rs10752637 polymorphism and its association with Alzheimer's disease.},
  author={Li Mei Zhong and Qiu Dong-hai and Liu Hong-ying and Lei Qing-feng},
  journal={The European journal of neuroscience},
  year={2009},
  volume={30 9},
  pages={1831-6}
}
Alzheimer's disease (AD) is a common, degenerative form of dementia characterized by the accumulation of plaques containing amyloid beta-peptides (A beta). Nicastrin (NCSTN) is a type I trans-membrane glycoprotein and an essential component of gamma-secretase, a multiprotein complex required for the production of the mature form of A beta. Overexpression of… CONTINUE READING