Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.

@article{Grundner2005AnalysisOT,
  title={Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.},
  author={Christoph Grundner and Yuxing Li and Mark Louder and John R. Mascola and Xinzhen Yang and Joseph Sodroski and Richard Wyatt},
  journal={Virology},
  year={2005},
  volume={331 1},
  pages={33-46}
}
The elicitation of broadly neutralizing antibodies directed against the human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins, gp120 and gp41, remains a major challenge. Attempts to utilize monomeric gp120 as an immunogen to elicit high titers of neutralizing antibodies have been disappointing. Envelope glycoprotein constructs that better reflect the trimeric structure of the functional envelope spike have exhibited improved immunogenicity compared with monomeric gp120. We have… CONTINUE READING
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