Analysis of the natively unstructured RNA/protein-recognition core in the Escherichia coli RNA degradosome and its interactions with regulatory RNA/Hfq complexes

@inproceedings{Bruce2018AnalysisOT,
  title={Analysis of the natively unstructured RNA/protein-recognition core in the Escherichia coli RNA degradosome and its interactions with regulatory RNA/Hfq complexes},
  author={Heather A Bruce and Dijun Du and Dijana Matak-Vinkov{\'i}c and Katarzyna J. Bandyra and R. William Broadhurst and Esther M. Martin and Frank Sobott and Alexander V. Shkumatov and Ben F Luisi},
  booktitle={Nucleic acids research},
  year={2018}
}
The RNA degradosome is a multi-enzyme assembly that plays a central role in the RNA metabolism of Escherichia coli and numerous other bacterial species including pathogens. At the core of the assembly is the endoribonuclease RNase E, one of the largest E. coli proteins and also one that bears the greatest region predicted to be natively unstructured. This extensive unstructured region, situated in the C-terminal half of RNase E, is punctuated with conserved short linear motifs that recruit… CONTINUE READING