Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.

@article{Nedal2007AnalysisOT,
  title={Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.},
  author={Aina Nedal and H{\aa}vard Sletta and Trygve Brautaset and Sven E.F. Borgos and Olga N. Sekurova and Trond E. Ellingsen and Sergey B Zotchev},
  journal={Applied and environmental microbiology},
  year={2007},
  volume={73 22},
  pages={7400-7}
}
The polyene macrolide antibiotic nystatin produced by Streptomyces noursei contains a deoxyaminosugar mycosamine moiety attached to the C-19 carbon of the macrolactone ring through the beta-glycosidic bond. The nystatin biosynthetic gene cluster contains three genes, nysDI, nysDII, and nysDIII, encoding enzymes with presumed roles in mycosamine biosynthesis and attachment as glycosyltransferase, aminotransferase, and GDP-mannose dehydratase, respectively. In the present study, the functions of… CONTINUE READING
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