Analysis of the murine phosphoinositide 3-kinase gamma gene.

  title={Analysis of the murine phosphoinositide 3-kinase gamma gene.},
  author={Emilio Hirsch and Matthias P Wymann and Emanuela Patrucco and Emanuela Tolosano and G Bulgarelli-Leva and Samanta Marengo and Mariano Rocchi and Fiorella Altruda},
  volume={256 1-2},
Phosphoinositide 3-kinase gamma is preferentially expressed in leukocytes. PI3Kgamma is activated by betagamma subunits of heterotrimeric G-proteins, which thus link seven transmembrane helix receptor activation to phosphatidylinositol (3,4,5)-trisphosphate production. Here we describe the molecular cloning of the murine PI3Kgamma cDNA, the PI3Kgamma gene structure, its chromosomal assignment and the analysis of promoter activity. The mouse cDNA shares 86% identity to its pig and human… CONTINUE READING

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