Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity.

Abstract

The murine Pax-3 protein contains two DNA-binding domains, a paired domain and a homeodomain, and alterations in the Pax-3 gene are responsible for the neural tube defects observed in the Splotch (Sp) mouse mutant. Of five Sp alleles, Splotch-delayed (Spd) is the only one that encodes a full-length Pax-3 protein, containing a single glycine-to-arginine… (More)

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@article{Underhill1995AnalysisOT, title={Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity.}, author={Darrell Alan Underhill and Kyle J. Vogan and P. Gros}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1995}, volume={92 9}, pages={3692-6} }