Analysis of the mouse 129-strain Nkrp1-Clr gene cluster reveals conservation of genomic organization and functional receptor–ligand interactions despite significant allelic polymorphism

@article{Chen2011AnalysisOT,
  title={Analysis of the mouse 129-strain Nkrp1-Clr gene cluster reveals conservation of genomic organization and functional receptor–ligand interactions despite significant allelic polymorphism},
  author={Peter C. Y. Chen and Simon B{\'e}langer and Oscar A Aguilar and Qiang Zhang and Aaron St.-Laurent and M. Munir Ahmad Rahim and Andrew P. Makrigiannis and James R. Carlyle},
  journal={Immunogenetics},
  year={2011},
  volume={63},
  pages={627-640}
}
The Nkrp1 (Klrb) family of NK cell receptors and their genetically linked Clr (Clec2) ligands are conserved between rodents and humans. Nonetheless, certain mouse and rat Nkrp1 genes exhibit significant allelic polymorphism between inbred strains. We previously demonstrated that the Nkrp1–Clr recognition system is genetically and functionally conserved between the B6 and BALB/c strains, with focused sequence divergence evident in certain genes (e.g., Nkrp1b,c). Here, we extend this finding by… CONTINUE READING