Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling.

@article{ChimalMonroy2003AnalysisOT,
  title={Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling.},
  author={Jes{\'u}s Chimal-Monroy and Joaqu{\'i}n Rodr{\'i}guez-Le{\'o}n and Juan A Montero and Yolanda Ga{\~n}an and Domingo Mac{\'i}as and Ram{\'o}n Merino and Juan M Hurle},
  journal={Developmental biology},
  year={2003},
  volume={257 2},
  pages={292-301}
}
Here, we have studied how Sox genes and BMP signaling are functionally coupled during limb chondrogenesis. Using the experimental model of TGFbeta1-induced interdigital digits, we dissect the sequence of morphological and molecular events during in vivo chondrogenesis. Our results show that Sox8 and Sox9 are the most precocious markers of limb cartilage, and their induction is independent and precedes the activation of BMP signaling. Sox10 appears also to cooperate with Sox9 and Sox8 in the… CONTINUE READING