Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate

Abstract

Caspase-2 is an evolutionarily conserved but enigmatic protease whose biological role remains poorly understood. To date, research into the functions of caspase-2 has been hampered by an absence of reagents that can distinguish its activity from that of the downstream apoptotic caspase, caspase-3. Identification of protein substrates of caspase-2 that are… (More)

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Cite this paper

@inproceedings{Kitevska2014AnalysisOT, title={Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate}, author={Tanja Kitevska and Sarah J. Roberts and Delara Pantaki-Eimany and Sarah E. Boyd and Fiona L. Scott and Christine J. Hawkins}, booktitle={Bioscience reports}, year={2014} }