Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

@article{Palavalli2009AnalysisOT,
  title={Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma},
  author={Lavanya H Palavalli and Todd D. Prickett and John R. Wunderlich and Xiaomu Wei and Allison S Burrell and Patricia Porter-Gill and Sean Davis and Chenwei Wang and Julia C Cronin and Neena Stephanie Agrawal and Jimmy Cheng-Ho Lin and Wendy Westbroek and Shelley L. Hoogstraten-Miller and Alfredo A Molinolo and Patricia A. Fetsch and Armando Carlos Filie and Michael P. O'Connell and Carolyn E. Banister and Jason D. Howard and Phillip J. Buckhaults and Ashani T Weeraratna and Lawrence C. Brody and Steven A Rosenberg and Yardena Samuels},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={518-520}
}
A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.