Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease.

@article{Russell2006AnalysisOT,
  title={Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease.},
  author={Richard Russell and Hazel E. Drummond and Elaine R. Nimmo and Niall H. Anderson and Colin L. Noble and David C. Wilson and Peter M. Gillett and P Mcgrogan and Kamal Hassan and Lawrence T Weaver and William Michael Bisset and Gamal Mahdi and Jack Satsangi},
  journal={Gut},
  year={2006},
  volume={55 8},
  pages={1114-23}
}
BACKGROUND AND AIMS The OCTN1 (SLC22A4 1672C-->T) and OCTN2 (SLC22A5 -207G-->C) variants within the IBD5 locus have been associated with susceptibility to adult onset Crohn's disease (CD), but their contribution in children has not been examined. METHODS These OCTN1/2 variants and IBD5 marker single nucleotide polymorphisms (SNPs) (IGR2096a_1, IGR2198a_1, and IGR2230a_1) were examined in 299 Scottish children (200 with CD, 74 with ulcerative colitis (UC), and 25 with indeterminate colitis (IC… CONTINUE READING