Analysis of the individual contributions of Igalpha (CD79a)- and Igbeta (CD79b)-mediated tonic signaling for bone marrow B cell development and peripheral B cell maturation.

@article{FuentesPanan2006AnalysisOT,
  title={Analysis of the individual contributions of Igalpha (CD79a)- and Igbeta (CD79b)-mediated tonic signaling for bone marrow B cell development and peripheral B cell maturation.},
  author={Ezequiel M Fuentes-Panan{\'a} and Gregory Bannish and Fredrick G. Karnell and John F. Treml and John Monroe},
  journal={Journal of immunology},
  year={2006},
  volume={177 11},
  pages={7913-22}
}
The individual contribution of Igalpha and Igbeta for BCR-triggered fates is unclear. Prior evidence supports conflicting ideas concerning unique as well as redundant functions for these proteins in the context of BCR/pre-BCR signaling. Part of this ambiguity may reflect the recent appreciation that Igalpha and Igbeta participate in both Ag-independent (tonic) and Ag-dependent signaling. The present study undertook defining the individual requirement for Igalpha and Igbeta under conditions… CONTINUE READING