Analysis of the in vivo functions of Mrp3.

@article{Belinsky2005AnalysisOT,
  title={Analysis of the in vivo functions of Mrp3.},
  author={Martin G Belinsky and Paul A. Dawson and Irina Shchaveleva and Lisa J. Bain and Renxue Wang and Victor Ling and Zhe-Sheng Chen and A. S. Grinberg and Heiner Westphal and Andr{\'e}s J. P. Klein-Szanto and Anthony Lerro and Gary D. Kruh},
  journal={Molecular pharmacology},
  year={2005},
  volume={68 1},
  pages={
          160-8
        }
}
  • Martin G Belinsky, Paul A. Dawson, +9 authors Gary D. Kruh
  • Published in Molecular pharmacology 2005
  • Medicine, Biology
  • Multidrug resistance protein 3 (MRP3) is an ATP-binding cassette transporter that is able to confer resistance to anticancer agents such as etoposide and to transport lipophilic anions such as bile acids and glucuronides. These capabilities, along with the induction of the MRP3 protein on hepatocyte sinusoidal membranes in cholestasis and the expression of MRP3 in enterocytes, have led to the hypotheses that MRP3 may function in the body to protect normal tissues from etoposide, to protect… CONTINUE READING

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