Analysis of the human cancer glycome identifies a novel group of tumor-associated N-acetylglucosamine glycan antigens.

@article{Satomaa2009AnalysisOT,
  title={Analysis of the human cancer glycome identifies a novel group of tumor-associated N-acetylglucosamine glycan antigens.},
  author={Tero Satomaa and Annamari Heiskanen and Ir{\'e}ne Leonardsson and Jonas {\AA}ngstr{\"o}m and Anne Olonen and Maria Blomqvist and Noora Salovuori and Caj Haglund and Susann Teneberg and Jari Natunen and Olli Carp{\'e}n and Juhani O. Saarinen},
  journal={Cancer research},
  year={2009},
  volume={69 14},
  pages={
          5811-9
        }
}
The cell surface is covered by a dense layer of protein- and lipid-linked glycans. Although it has been known that distinct glycan structures are associated with cancer, the whole spectrum of cancer-associated glycans has remained undiscovered. In the present study, we analyzed the protein-linked cancer glycome by matrix-assisted laser desorption/ionization time-of-flight mass spectrometric glycan profiling of cancer patient tissue samples. In lung cancer, we detected accumulation of a novel… CONTINUE READING

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