Analysis of the human VPS13 gene family.

@article{VelayosBaeza2004AnalysisOT,
  title={Analysis of the human VPS13 gene family.},
  author={Antonio Velayos-Baeza and Andrea Vettori and R. R. Copley and Carol Dobson-Stone and Anthony P Monaco},
  journal={Genomics},
  year={2004},
  volume={84 3},
  pages={536-49}
}
The gene mutated in chorea-acanthocytosis (CHAC; approved gene symbol VPS13A) encodes chorein, a protein similar to yeast Vps13p. We detected several similar putative human proteins by BLAST analysis of chorein. We characterized the structure of three new genes encoding these CHAC-similar proteins, located on chromosomes 1p36, 8q22, and 15q21. The most similar gene in yeast to all four human genes is Vps13, and therefore the human genes were named VPS13A (CHAC, 9q21), VPS13B (8q22), VPS13C… CONTINUE READING

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