Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors.

@article{Kortenhorst2013AnalysisOT,
  title={Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors.},
  author={Madeleine Susanne Quirine Kortenhorst and Michel Wissing and Ronald Rodriguez and Sushant K. Kachhap and Judith J. M. Jans and Petra van der Groep and Henk M W Verheul and Anuj Gupta and Paul Aiyetan and Elsken W A van der Wall and Michael Anthony Carducci and Paul J van Diest and Luigi Marchionni},
  journal={Epigenetics},
  year={2013},
  volume={8 9},
  pages={907-20}
}
Histone deacetylases (HDACs) have emerged as important targets for cancer treatment. HDAC-inhibitors (HDACis) are well tolerated in patients and have been approved for the treatment of patients with cutaneous T-cell lymphoma (CTCL). To improve the clinical benefit of HDACis in solid tumors, combination strategies with HDACis could be employed. In this study, we applied Analysis of Functional Annotation (AFA) to provide a comprehensive list of genes and pathways affected upon HDACi-treatment in… CONTINUE READING
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