Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis

@article{Liiv2005AnalysisOT,
  title={Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis},
  author={Aivar Liiv and Diana Karitkina and {\"U}lo Maiv{\"a}li and Jaanus Remme},
  journal={BMC Molecular Biology},
  year={2005},
  volume={6},
  pages={18 - 18}
}
BackgroundThe ribosome is a two-subunit enzyme known to exhibit structural dynamism during protein synthesis. The intersubunit bridges have been proposed to play important roles in decoding, translocation, and the peptidyl transferase reaction; yet the physical nature of their contributions is ill understood. An intriguing intersubunit bridge, B2a, which contains 23S rRNA helix 69 as a major component, has been implicated by proximity in a number of catalytically important regions. In addition… CONTINUE READING

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