Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis

  title={Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis},
  author={A. Liiv and Diana Karitkina and {\"U}. Maiv{\"a}li and J. Remme},
  journal={BMC Molecular Biology},
  pages={18 - 18}
  • A. Liiv, Diana Karitkina, +1 author J. Remme
  • Published 2005
  • Biology, Medicine
  • BMC Molecular Biology
  • BackgroundThe ribosome is a two-subunit enzyme known to exhibit structural dynamism during protein synthesis. The intersubunit bridges have been proposed to play important roles in decoding, translocation, and the peptidyl transferase reaction; yet the physical nature of their contributions is ill understood. An intriguing intersubunit bridge, B2a, which contains 23S rRNA helix 69 as a major component, has been implicated by proximity in a number of catalytically important regions. In addition… CONTINUE READING
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