Analysis of the enantiomers of VX using normal-phase chiral liquid chromatography with atmospheric pressure chemical ionization-mass spectrometry.

Abstract

The chemical warfare nerve agent O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) is a mixture of two enantiomers resulting from the chiral center at the phosphorus atom. Significant differences exist in the reported toxicity and acetylcholinesterase inhibition rates of the two enantiomers. This makes the ability to distinguish between them… (More)

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