Analysis of the electrophysiological properties and arrhythmias in directly contacted skeletal and cardiac muscle cell sheets.

@article{Itabashi2005AnalysisOT,
  title={Analysis of the electrophysiological properties and arrhythmias in directly contacted skeletal and cardiac muscle cell sheets.},
  author={Yuji Itabashi and Shunichiro Miyoshi and Shinsuke Yuasa and Jun Fujita and Tatsuya Shimizu and T. Okano and Keiichi Fukuda and Satoshi Ogawa},
  journal={Cardiovascular research},
  year={2005},
  volume={67 3},
  pages={561-70}
}
OBJECTIVE Autologous skeletal muscle cell (SM) transplantation into the in vivo heart sometimes induces serious arrhythmias. The purpose of this study was to investigate the electrophysiology of cardiomyocyte (CM) and SM in direct contact and to study the mechanism underlying the cause of arrhythmia using the recently developed cell sheet engineering technique. METHODS Primary cultured rat neonatal SM and CM were prepared, and cell sheets were fabricated using temperature-responsive culture… CONTINUE READING
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