Analysis of the electrophysiologic effects of short-term oxybutynin on guinea pig and rabbit ventricular cells.

@article{Jones2000AnalysisOT,
  title={Analysis of the electrophysiologic effects of short-term oxybutynin on guinea pig and rabbit ventricular cells.},
  author={Stephen E Jones and Y Kasamaki and Lesya M. Shuba and Toshitsugu Ogura and JOHN R. MCCULLOUGH and T. F. Mcdonald},
  journal={Journal of cardiovascular pharmacology},
  year={2000},
  volume={35 2},
  pages={334-40}
}
The objective of this study was to investigate the cardioactive properties of oxybutynin, a drug that is widely prescribed for management of voiding dysfunction. Membrane currents were recorded from whole-cell-configured guinea pig ventricular myocytes, and action potentials were recorded from guinea pig and rabbit papillary muscles. L-type Ca2+ current (I(Ca),L), inward-rectifier K+ current (I(K1)), and delayed-rectifier K+ current (I(K)) were unaffected by < or = 1 microM oxybutynin, and… CONTINUE READING