Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids.

@article{Chivers2006AnalysisOT,
  title={Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids.},
  author={Joanna E. Chivers and Wei Gong and Elizabeth Monroe King and Joachim Seybold and Judith C W Mak and Louise E Donnelly and Neil S. Holden and Robert Newton},
  journal={Molecular pharmacology},
  year={2006},
  volume={70 6},
  pages={
          2084-95
        }
}
Although repression of inflammatory gene expression makes glucocorticoids powerful anti-inflammatory agents, side effects limit usage and drive the search for improved glucocorticoid receptor (GR) ligands. In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 (Mol Endocrinol 11:1245-1255, 1997) repress interleukin (IL)-1beta-induced expression of cyclooxygenase (COX)-2 and IL-8. Although RU24858 is a weaker GR ligand, both glucocorticoids showed similar… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide.

  • British journal of pharmacology
  • 2012
VIEW 9 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Influence of dexamethasone on protease-activated receptor 2-mediated responses in the airways.

  • The Journal of pharmacology and experimental therapeutics
  • 2007
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Antiinflammatory action of glucocorticoids--new mechanisms for old drugs.

  • The New England journal of medicine
  • 2005
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Molecular mechanisms of corticosteroids in allergic diseases

PJ Barnes
  • Allergy
  • 2001
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL