Analysis of the dihydropyridine receptor site of L-type calcium channels by alanine-scanning mutagenesis.

@article{Peterson1997AnalysisOT,
  title={Analysis of the dihydropyridine receptor site of L-type calcium channels by alanine-scanning mutagenesis.},
  author={Blaise Z. Peterson and Brody Dylan Johnson and Gregory H. Hockerman and Marita B Acheson and Todd Scheuer and William A. Catterall},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 30},
  pages={18752-8}
}
The dihydropyridine Ca2+ antagonist drugs used in the therapy of cardiovacular disorders inhibit L-type Ca2+ channels by binding to a single high affinity site. Photoaffinity labeling and analysis of mutant Ca2+ channels implicate the IIIS6 and IVS6 segments in high affinity binding. The amino acid residues that are required for high affinity binding of dihydropyridine Ca2+ channel antagonists were probed by alanine-scanning mutagenesis of the alpha1C subunit, transient expression in mammalian… CONTINUE READING

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Molecular Determinants of Dihydropyridine Binding 18758 at D na M eical Lirary, U nirsity of V rm nt on O cber 12

G. H. Hockerman, B. D. Johnson, M. R. Abbott, T. Scheuer, W. A. Catterall
J. Biol. Chem. 272, • 1997
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Cold Spring Harbor Symp

R. J. Gould, K. M. Murphy, S. H. Snyder
Quant . Biol • 1983

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