Analysis of the cytogenetic stability of the human embryonal kidney cell line 293 by cytogenetic and STR profiling approaches.

@article{Bylund2004AnalysisOT,
  title={Analysis of the cytogenetic stability of the human embryonal kidney cell line 293 by cytogenetic and STR profiling approaches.},
  author={Lovisa Bylund and Soili Kyt{\"o}l{\"a} and W-O Lui and C Larsson and Gerd R. Weber},
  journal={Cytogenetic and genome research},
  year={2004},
  volume={106 1},
  pages={28-32}
}
We have characterized the cytogenetic alterations of the human embryonal cell line 293 by spectral karyotyping and G-banding analysis. To investigate its genomic stability, we compared the karyotypes of 293 and its daughter line EcR-293. Genotype profiling through short tandem repeats complemented the analysis. While displaying almost identical STR profiles and thus verifying their origin and their close relation, the two lines were remarkably different in their number of chromosomes and setup… CONTINUE READING

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