Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP.

@article{Uchime2012AnalysisOT,
  title={Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP.},
  author={Onyinyechukwu Uchime and R. Ortega Herrera and Karine Reiter and Svetlana Kotova and Richard L. Shimp and Kazutoyo Miura and Dominique Jones and Jacob Lebowitz and Xavier I. Ambroggio and Darrell E Hurt and Albert J Jin and Carole A. Long and Louis H. Miller and David L. Narum},
  journal={Eukaryotic cell},
  year={2012},
  volume={11 5},
  pages={615-25}
}
Thrombospondin repeat (TSR)-like domains are structures involved with cell adhesion. Plasmodium falciparum proteins containing TSR domains play crucial roles in parasite development. In particular, the preerythrocytic P. falciparum circumsporozoite protein is involved in hepatocyte invasion. The importance of these domains in two other malaria proteins, the merozoite-specific thrombospondin-related anonymous protein (MTRAP) and the thrombospondin-related apical membrane protein (PTRAMP), were… CONTINUE READING

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