Analysis of the cardiotoxic effect of isoproterenol in chick embryo.

@article{Odal1982AnalysisOT,
  title={Analysis of the cardiotoxic effect of isoproterenol in chick embryo.},
  author={Bohuslav O{\vs}ť{\'a}dal and Tatiana Janatov{\'a} and E G Krause and Z. Rychter and V{\'a}clav Pelouch},
  journal={Journal de physiologie},
  year={1982},
  volume={78 9},
  pages={867-9}
}
Intraamnial administration of isoproterenol (IPRO) to chick embryo induces different types of pathological changes of the myocardial and liver tissue: their character depends upon the developmental period during which the drug was administered. Analysis of the embryotoxic effect of IPRO has revealed that the time-course of in vivo uptake of [3H]IPRO by the developing heart appears to present the same pattern as the embryonic liver tissue; both peak values (10 min and 6 h after injection) were… CONTINUE READING