Analysis of the autoantibody repertoire in Burkitt’s lymphoma patients: frequent response against the transcription factor ATF-2

@article{Kersten2004AnalysisOT,
  title={Analysis of the autoantibody repertoire in Burkitt’s lymphoma patients: frequent response against the transcription factor ATF-2},
  author={Christian Kersten and Jan Delabie and Gustav Gaudernack and Erlend Smeland and Alexander Foss{\aa}},
  journal={Cancer Immunology, Immunotherapy},
  year={2004},
  volume={53},
  pages={1119-1126}
}
In the last few years, serological identification of tumour-associated antigens (TAAs) by recombinant cDNA expression cloning (SEREX) has enabled the mapping of humoral immune responses against TAAs in various types of cancer. The present paper describes the application of SEREX to Burkitt’s lymphoma (BL), a malignancy not previously characterized by SEREX. By using a cDNA library from a BL cell line that does not express IgG, technical difficulties related to background immunoglobulin clones… CONTINUE READING

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Autoantibody responses against ATF-2 were detected by ELISA in 6 of 8 BL patients , compared with 6 of 13 patients with T - cell non - Hodgkin ’s lymphoma ( T - NHL ) , 5 of 23 patients with follicular lymphoma and 2 of 27 diffuse large B - cell lymphoma patients .
Autoantibody responses against ATF-2 were detected by ELISA in 6 of 8 BL patients , compared with 6 of 13 patients with T - cell non - Hodgkin ’s lymphoma ( T - NHL ) , 5 of 23 patients with follicular lymphoma and 2 of 27 diffuse large B - cell lymphoma patients .
Autoantibody responses against ATF-2 were detected by ELISA in 6 of 8 BL patients , compared with 6 of 13 patients with T - cell non - Hodgkin ’s lymphoma ( T - NHL ) , 5 of 23 patients with follicular lymphoma and 2 of 27 diffuse large B - cell lymphoma patients .
Autoantibody responses against ATF-2 were detected by ELISA in 6 of 8 BL patients , compared with 6 of 13 patients with T - cell non - Hodgkin ’s lymphoma ( T - NHL ) , 5 of 23 patients with follicular lymphoma and 2 of 27 diffuse large B - cell lymphoma patients .
Autoantibody responses against ATF-2 were detected by ELISA in 6 of 8 BL patients , compared with 6 of 13 patients with T - cell non - Hodgkin ’s lymphoma ( T - NHL ) , 5 of 23 patients with follicular lymphoma and 2 of 27 diffuse large B - cell lymphoma patients .
Autoantibody responses against ATF-2 were detected by ELISA in 6 of 8 BL patients , compared with 6 of 13 patients with T - cell non - Hodgkin ’s lymphoma ( T - NHL ) , 5 of 23 patients with follicular lymphoma and 2 of 27 diffuse large B - cell lymphoma patients .
Autoantibody responses against ATF-2 were detected by ELISA in 6 of 8 BL patients , compared with 6 of 13 patients with T - cell non - Hodgkin ’s lymphoma ( T - NHL ) , 5 of 23 patients with follicular lymphoma and 2 of 27 diffuse large B - cell lymphoma patients .
Autoantibody responses against ATF-2 were detected by ELISA in 6 of 8 BL patients , compared with 6 of 13 patients with T - cell non - Hodgkin ’s lymphoma ( T - NHL ) , 5 of 23 patients with follicular lymphoma and 2 of 27 diffuse large B - cell lymphoma patients .
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