Analysis of the adenovirus type 5 terminal protein precursor and DNA polymerase by linker insertion mutagenesis.

Abstract

A series of adenovirus type 5 precursor terminal protein (pTP) and DNA polymerase (Ad pol) genes with linker insertion mutations were separately introduced into the vaccinia virus genome under the control of a late vaccinia virus promoter. The recombinant viruses were used for overexpression of the mutant genes in HeLa cells. In total, 22 different mutant… (More)

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@article{Roovers1993AnalysisOT, title={Analysis of the adenovirus type 5 terminal protein precursor and DNA polymerase by linker insertion mutagenesis.}, author={Dick J. Roovers and F M van der Lee and Jacqueline van der Wees and John S. Sussenbach}, journal={Journal of virology}, year={1993}, volume={67 1}, pages={265-76} }