Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints.


Chromosomal translocations and deletions are among the major events that initiate neoplasia. For lymphoid chromosomal translocations, misrecognition by the RAG (recombination activating gene) complex of V(D)J recombination is one contributing factor that has long been proposed. The chromosomal translocations involving LMO2 (t(11;14)(p13;q11)), Ttg-1 (t(11… (More)

7 Figures and Tables


  • Presentations referencing similar topics