Analysis of the UNC13A gene as a risk factor for sporadic amyotrophic lateral sclerosis.


A myotrophic lateral sclerosis (ALS) is an adultonset neurodegenerative disease characterized by progressive loss of motor neurons from the spinal cord, brainstem, and cerebral cortex that typically results in death 2 to 5 years following onset. Approximately 10% of patients with ALS have a family history, of which 15% to 20% are linked to mutations in the… (More)
DOI: 10.1001/archneurol.2010.46


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