Analysis of the TSC2 gene in human medulloblastoma

  title={Analysis of the TSC2 gene in human medulloblastoma},
  author={Rene Przkora and Birgit Meyer-Puttlitz and Ottmar Schmitt and Frank Berthold and Markus M. N{\"o}then and Juergen Krauss and Joerg Christian Tonn and Andreas von Deimling and Otmar Dieter Wiestler and Torsten Pietsch},
  journal={Acta Neuropathologica},
Medulloblastoma (MB) represents the most frequent malignant brain tumor of childhood. Recent studies have shown that deregulation of developmental control genes may play an important role in its pathogenesis. Tuberous sclerosis is associated with hamartomas and cortical tubers, consisting of both glial and neuronal cellular components. MBs can also show markers of these lineages, raising the question of the potential involvement of TSC genes in these malignant tumors. Here we investigated… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 24 references

Gigas , a Drosophila homolog of tuberous sclerosis gene product2 , regulates the cell cycle

V Jay, LE Becker, H Otsubo
Cell • 1999

Alterations in the rap 1 signaling pathway are common in human gliomas

EP Henske, Neumann HPH, +3 authors DJ Kwiatkowski
Oncogene • 1997

Iden - tification of the tuberous sclerosis gene TSC 1 on chromosome 9 q 34

Slegtenhorst M van, Hoogt R de, C Hermans
Science • 1997

Suppression of the neoplastic phenotype by replacement of the Tsc 2 gene in Eker Rat renal carcinoma cells

T Pietsch, T Scharmann, +7 authors H Riehm
Biochem Biophys Res Commun • 1996

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