Analysis of the TCR V γ repertoire in healthy donors and HIV-1-infected individuals

@inproceedings{Wesch1998AnalysisOT,
  title={Analysis of the TCR V γ repertoire in healthy donors and HIV-1-infected individuals},
  author={Daniela Wesch and Thomas Hinz and Dieter Kabelitz},
  year={1998}
}
During the course of infection with HIV-1, striking alterations in the subset distribution of peripheral blood γδ T cells are observed. While TCR V δ2 expression dominates among peripheral blood γδ T cells in healthy adults, there is a clear preponderance of V δ1 cells in HIV-1-infected persons. In this study, we present the first flow cytometry (FCM) analysis of the complete TCR V γ gene repertoire in HIV-1-infected individuals using a panel of mAb against all expressed V γ genes. The… CONTINUE READING