Corpus ID: 35711135

Analysis of the S 3 and S 3 * subsite specificities of feline immunodeficiency virus ( FIV ) protease : Development of a broad-based protease inhibitor efficacious against FIV , SIV , and HIV in vitro and ex vivo

@inproceedings{Lee1998AnalysisOT,
  title={Analysis of the S 3 and S 3 * subsite specificities of feline immunodeficiency virus ( FIV ) protease : Development of a broad-based protease inhibitor efficacious against FIV , SIV , and HIV in vitro and ex vivo},
  author={T. Lee and G. Laco and B. Torbett and H. Fox and D. L. Lerner and J. Elder and C. Wong},
  year={1998}
}

T. Lee, G. Laco, +4 authors C. Wong

Published 1998

The S3 and S3* subsite binding specificities of HIV and feline immunodeficiency virus proteases (FIV) proteases (PRs) have been explored by using C2-symmetric competitive inhibitors. The inhibitors evaluated contained (1S, 2R, 3R, 4S)-1,4-diamino-1,4-dibenzyl-2,3-diol as P1 and P1* units, Val as P2 and P2* residues, and a variety of amino acids at the P3 and P3* positions. All inhibitors showed very high potency against HIV PR in vitro, and their Ki values ranged between 1.1 and 2.6 nM. In… CONTINUE READING

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