Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients.

@article{Zheng2011AnalysisOT,
  title={Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients.},
  author={Yun Zheng and Youwei Zhang and Xiang Huang and Longbang Chen},
  journal={Hepato-gastroenterology},
  year={2011},
  volume={58 112},
  pages={2007-11}
}
BACKGROUND/AIMS Human runt-related transcription factor 3 (RUNX3) gene was a new candidate tumor suppressor gene involved in the TGF-β signaling pathway. We evaluated the diagnostic role of RUNX3 gene methylation in serum DNA of esophageal squamous cell carcinoma (ESCC), gastric cancer (GC) and colorectal cancer (CRC) patients. METHODOLOGY Methylation-specific polymerase chain reaction (MSP) was used to determine the promoter methylation status of RUNX3 gene in serum DNA. The combination of… CONTINUE READING

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