Analysis of the RELN gene as a genetic risk factor for autism

@article{Skaar2005AnalysisOT,
  title={Analysis of the RELN gene as a genetic risk factor for autism},
  author={David A. Skaar and Yi ‐ Min Shao and Jonathan L. Haines and Judith E. Stenger and Jacek Jaworski and Eden R. Martin and G. Robert Delong and Jason. H. Moore and Jacob L. McCauley and James S. Sutcliffe and Allison E. Ashley-Koch and Michael L. Cuccaro and Susan E. Folstein and John R. Gilbert and Margaret A. Pericak-Vance},
  journal={Molecular Psychiatry},
  year={2005},
  volume={10},
  pages={563-571}
}
Several genome-wide screens have indicated the presence of an autism susceptibility locus within the distal long arm of chromosome 7 (7q). Mapping at 7q22 within this region is the candidate gene reelin (RELN). RELN encodes a signaling protein that plays a pivotal role in the migration of several neuronal cell types and in the development of neural connections. Given these neurodevelopmental functions, recent reports that RELN influences genetic risk for autism are of significant interest. The… CONTINUE READING

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