Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry

  title={Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry},
  author={Edwin Lasonder and Yasushi Ishihama and Jens S. Andersen and Adriaan M. W. Vermunt and Arnab Pain and Robert W. Sauerwein and Wijnand M. C. Eling and Neil Hall and Andrew P. Waters and Hendrik G. Stunnenberg and Matthias Mann},
The annotated genomes of organisms define a ‘blueprint’ of their possible gene products. Post-genome analyses attempt to confirm and modify the annotation and impose a sense of the spatial, temporal and developmental usage of genetic information by the organism. Here we describe a large-scale, high-accuracy (average deviation less than 0.02 Da at 1,000 Da) mass spectrometric proteome analysis of selected stages of the human malaria parasite Plasmodium falciparum. The analysis revealed 1,289… 
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