Analysis of the Pho regulon in Streptomyces tsukubaensis.

  title={Analysis of the Pho regulon in Streptomyces tsukubaensis.},
  author={Mar{\'i}a Ord{\'o}{\~n}ez-Robles and Fernando Santos-Beneit and Antonio Rodr{\'i}guez-Garc{\'i}a and Juan F. Martin},
  journal={Microbiological research},
Phosphate regulation of antibiotic biosynthesis in Streptomyces has been studied due to the importance of this genus as a source of secondary metabolites with biological activity. Streptomyces tsukubaensis is the main producer of tacrolimus (or FK506), an immunosuppressant macrolide that generates important benefits for the pharmaceutical market. However, the production of tacrolimus is under a negative control by phosphate and, therefore, is important to know the molecular mechanism of this… CONTINUE READING
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